Mechanical roles of apical constriction, cell elongation, and cell migration during neural tube formation in Xenopus
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چکیده
منابع مشابه
Mechanical roles of apical constriction, cell elongation, and cell migration during neural tube formation in Xenopus
Neural tube closure is an important and necessary process during the development of the central nervous system. The formation of the neural tube structure from a flat sheet of neural epithelium requires several cell morphogenetic events and tissue dynamics to account for the mechanics of tissue deformation. Cell elongation changes cuboidal cells into columnar cells, and apical constriction then...
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Apical constriction is an essential cell behavior during neural tube closure, but its underlying mechanisms are not fully understood. Lulu, or EPB4.1l5, is a FERM domain protein that has been implicated in apical constriction and actomyosin contractility in mouse embryos and cultured cells. Interference with the function of Lulu in Xenopus embryos by a specific antisense morpholino oligonucleot...
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ژورنال
عنوان ژورنال: Biomechanics and Modeling in Mechanobiology
سال: 2016
ISSN: 1617-7959,1617-7940
DOI: 10.1007/s10237-016-0794-1